Long-acting Erwinia chrysanthemi, Pegcrisantaspase, induces alternate amino acid biosynthetic pathways in a preclinical model of pancreatic ductal adenocarcinoma

Long-acting Erwinia chrysanthemi, Pegcrisantaspase, induces alternate amino acid biosynthetic pathways in a preclinical model of pancreatic ductal adenocarcinoma

Abstract Background Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease without meaningful therapeutic options beyond the first salvage therapy. Targeting PDAC metabolism through amino acid restriction has emerged as a promising new strategy, with asparaginases, enzymes that deplete pla...

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Bibliographic Details
Main Authors: Dominique Bollino, Kanwal Hameed, Anusha Bhat, Arveen Zarrabi, Andrea Casildo, Xinrong Ma, Kayla M Tighe, Brandon Carter-Cooper, Erin T. Strovel, Rena G. Lapidus, Ashkan Emadi
Format: Article
Language:English
Published: BMC 2024-06-01
Series:Cancer & Metabolism
Subjects:
Pancreatic cancer
KPC
Asparaginase
Glutamine
Asparagine
Pegcrisantaspase
Online Access:https://doi.org/10.1186/s40170-024-00346-2

Internet

https://doi.org/10.1186/s40170-024-00346-2

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