Caspase-1 Dependent IL-1β Secretion and Antigen-Specific T-Cell Activation by the Novel Adjuvant, PCEP

Caspase-1 Dependent IL-1β Secretion and Antigen-Specific T-Cell Activation by the Novel Adjuvant, PCEP

The potent adjuvant activity of the novel adjuvant, poly[di(sodiumcarboxylatoethylphenoxy)phosphazene] (PCEP), with various antigens has been reported previously. However, very little is known about its mechanisms of action. We have recently reported that intramuscular injection of PCEP induces NLR...

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Bibliographic Details
Main Authors: Sunita Awate, Nelson F. Eng, Volker Gerdts, Lorne A. Babiuk, George Mutwiri
Format: Article
Language:English
Published: MDPI AG 2014-06-01
Series:Vaccines
Subjects:
adjuvants
polyphosphazenes
inflammasomes
IL-1β
T-cells
Online Access:http://www.mdpi.com/2076-393X/2/3/500

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