Population Pharmacokinetics and Initial Dosage Optimization of Tacrolimus in Pediatric Hematopoietic Stem Cell Transplant Patients

Population Pharmacokinetics and Initial Dosage Optimization of Tacrolimus in Pediatric Hematopoietic Stem Cell Transplant Patients

Background: There is a substantial lack of tacrolimus pharmacokinetic information in pediatric hematopoietic stem cell transplant (HSCT) patients. This study aimed to develop population pharmacokinetics (PopPK) of tacrolimus in pediatric HSCT patients and to devise model-guided dosage regimens.Metho...

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Bibliographic Details
Main Authors: Xiao-Lin Liu, Yan-Ping Guan, Ying Wang, Ke Huang, Fu-Lin Jiang, Jian Wang, Qi-Hong Yu, Kai-Feng Qiu, Min Huang, Jun-Yan Wu, Dun-Hua Zhou, Guo-Ping Zhong, Xiao-Xia Yu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Pharmacology
Subjects:
tacrolimus
pediatric HSCT patients
population pharmacokinetics
Bayesian estimation
dosage simulation
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.891648/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.891648/full

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