Inducible localized delivery of an anti-PD-1 scFv enhances anti-tumor activity of ROR1 CAR-T cells in TNBC

Inducible localized delivery of an anti-PD-1 scFv enhances anti-tumor activity of ROR1 CAR-T cells in TNBC

Abstract Background Chimeric antigen receptor (CAR)-T cells can induce powerful immune responses in patients with hematological malignancies but have had limited success against solid tumors. This is in part due to the immunosuppressive tumor microenvironment (TME) which limits the activity of tumor...

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Bibliographic Details
Main Authors: Micaela Harrasser, Satyen Harish Gohil, Hiu Lau, Marco Della Peruta, Vincent Muczynski, Dominic Patel, Elena Miranda, Kristiana Grigoriadis, Anita Grigoriadis, David Granger, Rachel Evans, Amit Chunilal Nathwani
Format: Article
Language:English
Published: BMC 2022-06-01
Series:Breast Cancer Research
Subjects:
ROR1
CAR-T cell therapy
PD-1
Checkpoint blockade
F i-CAR-T cell
Single-chain variable fragment (scFv)
Online Access:https://doi.org/10.1186/s13058-022-01531-1

Internet

https://doi.org/10.1186/s13058-022-01531-1

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