Partners in Crime: Beta-Cells and Autoimmune Responses Complicit in Type 1 Diabetes Pathogenesis

Partners in Crime: Beta-Cells and Autoimmune Responses Complicit in Type 1 Diabetes Pathogenesis

Type 1 diabetes (T1D) is an autoimmune disease characterized by autoreactive T cell-mediated destruction of insulin-producing pancreatic beta-cells. Loss of beta-cells leads to insulin insufficiency and hyperglycemia, with patients eventually requiring lifelong insulin therapy to maintain normal gly...

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Bibliographic Details
Main Authors: Eliana Toren, KaLia S. Burnette, Ronadip R. Banerjee, Chad S. Hunter, Hubert M. Tse
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Immunology
Subjects:
beta-cell
beta-cell heterogeneity
pancreatic islet
autoimmunity
ER stress
oxidative stress
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.756548/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.756548/full

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