Mechanism by which nuclear factor-kappa beta (NF-kB) regulates ovine fetal pulmonary vascular smooth muscle cell proliferation

Mechanism by which nuclear factor-kappa beta (NF-kB) regulates ovine fetal pulmonary vascular smooth muscle cell proliferation

Platelet activating factor (PAF) modulates ovine fetal pulmonary hemodynamic. PAF acts through its receptors (PAFR) in pulmonary vascular smooth muscle cells (PVSMC) to phosphorylate and induce nuclear translocation of NF-kB p65 leading to PVSMC proliferation. However, the interaction of NF-kB p65 a...

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Bibliographic Details
Main Authors: Uchenna D. Ogbozor, Michael Opene, Lissette S. Renteria, Shaemion McBride, Basil O. Ibe
Format: Article
Language:English
Published: Elsevier 2015-09-01
Series:Molecular Genetics and Metabolism Reports
Subjects:
PAF receptor
NF-kB p65 signaling retinoblastoma protein
DNA binding
Online Access:http://www.sciencedirect.com/science/article/pii/S2214426915300112

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http://www.sciencedirect.com/science/article/pii/S2214426915300112

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