The pterin binding site of dihydropteroate synthase (DHPS): In silico screening and in vitro antibacterial activity of existing drugs

The pterin binding site of dihydropteroate synthase (DHPS): In silico screening and in vitro antibacterial activity of existing drugs

Antimicrobial resistance has rendered the sulfonamide class of antibiotics obsolete. An additional binding site on the dihydropteroate synthase (DHPS) enzyme, i.e., the pterin binding site, has been shown to be a valid alternative to the well-known para-aminobenzoic acid binding site. The aim of thi...

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Bibliographic Details
Main Authors: Maryké Shaw, Anél Petzer, Jacobus P. Petzer, Theunis T. Cloete
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:Results in Chemistry
Subjects:
Sulfonamides
Pterin binding site
Computer-aided drug design
Minimum inhibitory concentration
Enrichment factor
Receiver operating characteristic
Online Access:http://www.sciencedirect.com/science/article/pii/S2211715623001029

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http://www.sciencedirect.com/science/article/pii/S2211715623001029

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