The coronavirus proofreading exoribonuclease mediates extensive viral recombination.

Recombination is proposed to be critical for coronavirus (CoV) diversity and emergence of SARS-CoV-2 and other zoonotic CoVs. While RNA recombination is required during normal CoV replication, the mechanisms and determinants of CoV recombination are not known. CoVs encode an RNA proofreading exoribo...

Full description

Bibliographic Details
Main Authors: Jennifer Gribble, Laura J Stevens, Maria L Agostini, Jordan Anderson-Daniels, James D Chappell, Xiaotao Lu, Andrea J Pruijssers, Andrew L Routh, Mark R Denison
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-01-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1009226