Prenatal Mechanistic Target of Rapamycin Complex 1 (m TORC1) Inhibition by Rapamycin Treatment of Pregnant Mice Causes Intrauterine Growth Restriction and Alters Postnatal Cardiac Growth, Morphology, and Function

Prenatal Mechanistic Target of Rapamycin Complex 1 (m TORC1) Inhibition by Rapamycin Treatment of Pregnant Mice Causes Intrauterine Growth Restriction and Alters Postnatal Cardiac Growth, Morphology, and Function

BackgroundFetal growth impacts cardiovascular health throughout postnatal life in humans. Various animal models of intrauterine growth restriction exhibit reduced heart size at birth, which negatively influences cardiac function in adulthood. The mechanistic target of rapamycin complex 1 (mTORC1) in...

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Bibliographic Details
Main Authors: Maria Hennig, Saskia Fiedler, Christian Jux, Ludwig Thierfelder, Jörg‐Detlef Drenckhahn
Format: Article
Language:English
Published: Wiley 2017-08-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
cardiac function
cardiac growth
cardiac mass
fetal programming
heart development
intrauterine growth restriction
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.117.005506

Internet

https://www.ahajournals.org/doi/10.1161/JAHA.117.005506

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