Amyloid precursor protein controls cholesterol turnover needed for neuronal activity

Amyloid precursor protein controls cholesterol turnover needed for neuronal activity

Abstract Perturbation of lipid metabolism favours progression of Alzheimer disease, in which processing of Amyloid Precursor Protein (APP) has important implications. APP cleavage is tightly regulated by cholesterol and APP fragments regulate lipid homeostasis. Here, we investigated whether up or do...

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Bibliographic Details
Main Authors: Nathalie Pierrot, Donatienne Tyteca, Ludovic D'auria, Ilse Dewachter, Philippe Gailly, Aurélie Hendrickx, Bernadette Tasiaux, Laetitia El Haylani, Nathalie Muls, Francisca N'Kuli, Annie Laquerrière, Jean‐Baptiste Demoulin, Dominique Campion, Jean‐Pierre Brion, Pierre J. Courtoy, Pascal Kienlen‐Campard, Jean‐Noël Octave
Format: Article
Language:English
Published: Springer Nature 2013-04-01
Series:EMBO Molecular Medicine
Subjects:
Alzheimer's disease
calcium oscillations
cholesterol turnover
neuron
SREBP‐1
Online Access:https://doi.org/10.1002/emmm.201202215

Internet

https://doi.org/10.1002/emmm.201202215

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