Oxaliplatin resistance in colorectal cancer enhances TRAIL sensitivity via death receptor 4 upregulation and lipid raft localization

Oxaliplatin resistance in colorectal cancer enhances TRAIL sensitivity via death receptor 4 upregulation and lipid raft localization

Colorectal cancer (CRC) remains a leading cause of cancer death, and its mortality is associated with metastasis and chemoresistance. We demonstrate that oxaliplatin-resistant CRC cells are sensitized to TRAIL-mediated apoptosis. Oxaliplatin-resistant cells exhibited transcriptional downregulation o...

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Bibliographic Details
Main Authors: Joshua D Greenlee, Maria Lopez-Cavestany, Nerymar Ortiz-Otero, Kevin Liu, Tejas Subramanian, Burt Cagir, Michael R King
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-08-01
Series:eLife
Subjects:
lipid rafts
metastasis
TRAIL
death receptors
palmitoylation
Online Access:https://elifesciences.org/articles/67750

Internet

https://elifesciences.org/articles/67750

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