Structural Evolution of Primate Glutamate Dehydrogenase 2 as Revealed by In Silico Predictions and Experimentally Determined Structures

Structural Evolution of Primate Glutamate Dehydrogenase 2 as Revealed by In Silico Predictions and Experimentally Determined Structures

Glutamate dehydrogenase (GDH) interconverts glutamate to a-ketoglutarate and ammonia, interconnecting amino acid and carbohydrate metabolism. In humans, two functional GDH genes, <i>GLUD1</i> and <i>GLUD2</i>, encode for hGDH1 and hGDH2, respectively. <i>GLUD2</i>...

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Bibliographic Details
Main Authors: Ionela Litso, Andreas Plaitakis, Vasiliki E. Fadouloglou, Mary Providaki, Michael Kokkinidis, Ioannis Zaganas
Format: Article
Language:English
Published: MDPI AG 2023-12-01
Series:Biomolecules
Subjects:
glutamate dehydrogenase
AlphaFold
protein structure prediction
primate evolution
Online Access:https://www.mdpi.com/2218-273X/14/1/22

Internet

https://www.mdpi.com/2218-273X/14/1/22

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