Sex-dependent transcription of cardiac electrophysiology and links to acetylation modifiers based on the GTEx database

Development of safer drugs based on epigenetic modifiers, e.g., histone deacetylase inhibitors (HDACi), requires better understanding of their effects on cardiac electrophysiology. Using RNAseq data from the genotype-tissue-expression database (GTEx), we created models that link the abundance of ace...

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Détails bibliographiques
Auteurs principaux: Michael P. Pressler, Anelia Horvath, Emilia Entcheva
Format: Article
Langue:English
Publié: Frontiers Media S.A. 2022-07-01
Collection:Frontiers in Cardiovascular Medicine
Sujets:
Accès en ligne:https://www.frontiersin.org/articles/10.3389/fcvm.2022.941890/full