Piperine as Therapeutic Agent in Paracetamol-Induced Hepatotoxicity in Mice

Piperine as Therapeutic Agent in Paracetamol-Induced Hepatotoxicity in Mice

High doses of paracetamol (APAP) can cause irreversible liver damage. Piperine (P) inhibits cytochrome P450, which is involved in the metabolism of various xenobiotics, including paracetamol. We evaluated the hepatoprotective effects of piperine with or without N-acetylcysteine (NAC) in APAP-induced...

Full description

Bibliographic Details
Main Authors: Aline Meireles Coelho, Isabela Ferreira Queiroz, Luiza Oliveira Perucci, Melina Oliveira de Souza, Wanderson Geraldo Lima, André Talvani, Daniela Caldeira Costa
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Pharmaceutics
Subjects:
paracetamol
acetaminophen
piperine
redox status
inflamassome
Online Access:https://www.mdpi.com/1999-4923/14/9/1800

Internet

https://www.mdpi.com/1999-4923/14/9/1800

Similar Items