Mitochondrial uncoupling and the reprogramming of intermediary metabolism in leukemia cells

Mitochondrial uncoupling and the reprogramming of intermediary metabolism in leukemia cells

Nearly 60 years ago Otto Warburg proposed, in a seminal publication, that an irreparable defect in the oxidative capacity of normal cells supported the switch to glycolysis for energy generation and the appearance of the malignant phenotype (Warburg, 1956). Curiously, this phenotype was also observe...

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Bibliographic Details
Main Authors: Juliana eVélez, Numsen eHail, Marina eKonopleva, Zhihong eZeng, Kensuke eKojima, Ismael eSamudio, Michael eAndreeff
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-04-01
Series:Frontiers in Oncology
Subjects:
Apoptosis
Electron Transport
microenvironment
cataplerosis
OxPhos
Krebs cycle
Online Access:http://journal.frontiersin.org/Journal/10.3389/fonc.2013.00067/full

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http://journal.frontiersin.org/Journal/10.3389/fonc.2013.00067/full

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