Depletion of Labile Iron Induces Replication Stress and Enhances Responses to Chemoradiation in Non-Small-Cell Lung Cancer

Depletion of Labile Iron Induces Replication Stress and Enhances Responses to Chemoradiation in Non-Small-Cell Lung Cancer

The intracellular redox-active labile iron pool (LIP) is weakly chelated and available for integration into the iron metalloproteins that are involved in diverse cellular processes, including cancer cell-specific metabolic oxidative stress. Abnormal iron metabolism and elevated LIP levels are linked...

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Bibliographic Details
Main Authors: Khaliunaa Bayanbold, Mekhla Singhania, Melissa A. Fath, Charles C. Searby, Jeffrey M. Stolwijk, John B. Henrich, Casey F. Pulliam, Joshua D. Schoenfeld, Kranti A. Mapuskar, Sei Sho, Joseph M. Caster, Bryan G. Allen, Garry R. Buettner, Maria Spies, Prabhat C. Goswami, Michael S. Petronek, Douglas R. Spitz
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:Antioxidants
Subjects:
ferritin heavy chain
iron chelator
deferoxamine
labile iron pool
cell cycle
replication stress
Online Access:https://www.mdpi.com/2076-3921/12/11/2005

Internet

https://www.mdpi.com/2076-3921/12/11/2005

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