The microbial metabolite p-Cresol induces autistic-like behaviors in mice by remodeling the gut microbiota

The microbial metabolite p-Cresol induces autistic-like behaviors in mice by remodeling the gut microbiota

Abstract Background Autism spectrum disorders (ASD) are associated with dysregulation of the microbiota-gut-brain axis, changes in microbiota composition as well as in the fecal, serum, and urine levels of microbial metabolites. Yet a causal relationship between dysregulation of the microbiota-gut-b...

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Bibliographic Details
Main Authors: Patricia Bermudez-Martin, Jérôme A. J. Becker, Nicolas Caramello, Sebastian P. Fernandez, Renan Costa-Campos, Juliette Canaguier, Susana Barbosa, Laura Martinez-Gili, Antonis Myridakis, Marc-Emmanuel Dumas, Aurélia Bruneau, Claire Cherbuy, Philippe Langella, Jacques Callebert, Jean-Marie Launay, Joëlle Chabry, Jacques Barik, Julie Le Merrer, Nicolas Glaichenhaus, Laetitia Davidovic
Format: Article
Language:English
Published: BMC 2021-07-01
Series:Microbiome
Subjects:
Microbiota
Autism
Behavior
Reward system
Metabolite
p-Cresol
Online Access:https://doi.org/10.1186/s40168-021-01103-z

Internet

https://doi.org/10.1186/s40168-021-01103-z

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