Antisense-Based Progerin Downregulation in HGPS-Like Patients’ Cells

Antisense-Based Progerin Downregulation in HGPS-Like Patients’ Cells

Progeroid laminopathies, including Hutchinson-Gilford Progeria Syndrome (HGPS, OMIM #176670), are premature and accelerated aging diseases caused by defects in nuclear A-type Lamins. Most HGPS patients carry a de novo point mutation within exon 11 of the LMNA gene encoding A-type Lamins. This mutati...

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Bibliographic Details
Main Authors: Karim Harhouri, Claire Navarro, Camille Baquerre, Nathalie Da Silva, Catherine Bartoli, Frank Casey, Guedenon Koffi Mawuse, Yassamine Doubaj, Nicolas Lévy, Annachiara De Sandre-Giovannoli
Format: Article
Language:English
Published: MDPI AG 2016-07-01
Series:Cells
Subjects:
HGPS-like
MAD-B
antisense oligonucleotides
Progerin
Prelamin A Δ90
Prelamin A Δ35
Online Access:http://www.mdpi.com/2073-4409/5/3/31

Internet

http://www.mdpi.com/2073-4409/5/3/31

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