BAC cloning and heterologous expression of a giant biosynthetic gene cluster encoding antifungal neotetrafibricin in streptomyces rubrisoli

BAC cloning and heterologous expression of a giant biosynthetic gene cluster encoding antifungal neotetrafibricin in streptomyces rubrisoli

Polyene natural products including nystatin A1, amphotericin B, ECO-02301, and mediomycin belong to a large family of valuable antifungal polyketide compounds typically produced by soil actinomycetes. A previous study (Park et al., Front. Bioeng. Biotechnol., 2021, 9, 692340) isolated Streptomyces r...

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Bibliographic Details
Main Authors: Heung-Soon Park, Ji-Hee Park, Hye-Jin Kim, Seung-Hoon Kang, Si-Sun Choi, Eung-Soo Kim
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
streptomyces
antifungals
antibiotics
genome mining
heterologous expression
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2022.964765/full

Internet

https://www.frontiersin.org/articles/10.3389/fbioe.2022.964765/full

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