Integrated edge information and pathway topology for drug-disease associations

Summary: Drug repurposing is a promising approach to find new therapeutic indications for approved drugs. Many computational approaches have been proposed to prioritize candidate anticancer drugs by gene or pathway level. However, these methods neglect the changes in gene interactions at the edge le...

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Detalles Bibliográficos
Main Authors: Xianbin Li, Xiangzhen Zan, Tao Liu, Xiwei Dong, Haqi Zhang, Qizhang Li, Zhenshen Bao, Jie Lin
Formato: Artigo
Idioma:English
Publicado: Elsevier 2024-07-01
Series:iScience
Subjects:
Acceso en liña:http://www.sciencedirect.com/science/article/pii/S2589004224012501