Coexistence of a novel SV2B-ALK, EML4-ALK double-fusion in a lung poorly differentiated adenocarcinoma patient and response to alectinib: a case report and literature review

Coexistence of a novel SV2B-ALK, EML4-ALK double-fusion in a lung poorly differentiated adenocarcinoma patient and response to alectinib: a case report and literature review

BackgroundAnaplastic lymphoma kinase (ALK) rearrangement, the most common oncogenic rearrangement in lung adenocarcinoma, occurs in approximately 5% of non-small cell lung cancer (NSCLC) patients. EML4 gene is the most common partner of ALK rearrangement, and distinct EML4-ALK fusions differ in thei...

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Bibliographic Details
Main Authors: Huang Chen, Menglan Zhang, Liyan Bai, Yun Niu, Xiaowei Wang, Ruiying Jiang, Ye Wang, Qianqian Feng, Bei Wang, Tingli Dai, Mingming Yuan, Rongrong Chen, Yujuan Qi, Dingrong Zhong
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-12-01
Series:Frontiers in Oncology
Subjects:
alectinib
ALK double fusions
CNS metastases
NSCLC
SV2B-ALK novel fusion
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2024.1453259/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2024.1453259/full

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