Aldehyde dehydrogenase 2 has cardioprotective effects on myocardial ischaemia/reperfusion injury via suppressing mitophagy

Aldehyde dehydrogenase 2 has cardioprotective effects on myocardial ischaemia/reperfusion injury via suppressing mitophagy

Mitophagy, a selective form of autophagy, is excessively activated in myocardial ischemia/reperfusion (I/R). The study investigated whether aldehyde dehydrogenase (ALDH2) exerted its cardioprotective effect by regulating mitophagy. Myocardial infarct size and apoptosis after I/R in rats were amelior...

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Bibliographic Details
Main Authors: Wenqing eJi, Yuguo eChen, Shujian eWei, Panpan eHao, Junhui eXing
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-04-01
Series:Frontiers in Pharmacology
Subjects:
Reactive Oxygen Species
mitophagy
ALDH2
Alda-1
myocardial ischemia/reperfusion
mitochondrial superoxide
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2016.00101/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2016.00101/full

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