Comparison of pharmacokinetic parameters of ranolazine between diabetic and non-diabetic rats

Comparison of pharmacokinetic parameters of ranolazine between diabetic and non-diabetic rats

Objective(s): Diabetes mellitus (DM) affects the pharmacokinetics of drugs. Ranolazine is an antianginal drug that is prescribed in DM patients with angina. We decided to evaluate the effect of DM on the pharmacokinetics of ranolazine and its major metabolite CVT-2738 in rats.Materials and Methods:...

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Bibliographic Details
Main Authors: Habibeh Mashayekhi-sardoo, Hossein Kamali, Soghra Mehri, Amirhossein Sahebkar, Mohsen Imenshahidi, Amir Hooshang Mohammadpour
Format: Article
Language:English
Published: Mashhad University of Medical Sciences 2022-07-01
Series:Iranian Journal of Basic Medical Sciences
Subjects:
clearance
diabetes mellitus
pharmacokinetics
ranolazine
volume of distribution
Online Access:https://ijbms.mums.ac.ir/article_20646_6b6322fe9f40ebe8877e67759568761c.pdf

Internet

https://ijbms.mums.ac.ir/article_20646_6b6322fe9f40ebe8877e67759568761c.pdf

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