Evaluation of Antagonistic Effects of Metformin with Cisplatin in Gastric Cancer Cells

Metformin has recently been introduced as an anti-cancer agent. In this study, we evaluated the effect of metformin and metformin/cisplatin on human gastric MKN-45 cell line. When we used metformin alone, it could inhibit proliferation and induce apoptosis, but it diminish anti-proliferative effects...

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Bibliographic Details
Main Authors: Vahid Lesan, Seyed H Ghaffari, Jamile Salaramoli, Mansour Heidari, Masoumeh Rostami, Kamran Alimoghaddam, Ardeshir Ghavamzadeh
Format: Article
Language:English
Published: Tehran University of Medical Sciences 2014-09-01
Series:International Journal of Hematology-Oncology and Stem Cell Research
Subjects:
Online Access:https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/418