Evaluation of Antagonistic Effects of Metformin with Cisplatin in Gastric Cancer Cells

Evaluation of Antagonistic Effects of Metformin with Cisplatin in Gastric Cancer Cells

Metformin has recently been introduced as an anti-cancer agent. In this study, we evaluated the effect of metformin and metformin/cisplatin on human gastric MKN-45 cell line. When we used metformin alone, it could inhibit proliferation and induce apoptosis, but it diminish anti-proliferative effects...

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Bibliographic Details
Main Authors: Vahid Lesan, Seyed H Ghaffari, Jamile Salaramoli, Mansour Heidari, Masoumeh Rostami, Kamran Alimoghaddam, Ardeshir Ghavamzadeh
Format: Article
Language:English
Published: Tehran University of Medical Sciences 2014-09-01
Series:International Journal of Hematology-Oncology and Stem Cell Research
Subjects:
Akt
Cisplatin
Gastric cancer
Metformin
Survivin
mTOR
Online Access:https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/418

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