A Case of ALK-Rearranged Combined Lung Adenocarcinoma and Neuroendocrine Carcinoma with Diffuse Bone Metastasis and Partial Response to Alectinib
We report a rare case of stage IV pulmonary combined large-cell neuroendocrine carcinoma (LCNEC) and adenocarcinoma (ACA), both demonstrating anaplastic lymphoma kinase (<i>ALK</i>) rearrangement by IHC and FISH. This 61-year-old lifelong nonsmoking Asian woman presented with a cough, an...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-02-01
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| Series: | Current Oncology |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1718-7729/29/2/72 |
| _version_ | 1797481345081933824 |
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| author | Chloe A. Lim Norbert Banyi Tracy Tucker Diana N. Ionescu Barbara Melosky |
| author_facet | Chloe A. Lim Norbert Banyi Tracy Tucker Diana N. Ionescu Barbara Melosky |
| author_sort | Chloe A. Lim |
| collection | DOAJ |
| description | We report a rare case of stage IV pulmonary combined large-cell neuroendocrine carcinoma (LCNEC) and adenocarcinoma (ACA), both demonstrating anaplastic lymphoma kinase (<i>ALK</i>) rearrangement by IHC and FISH. This 61-year-old lifelong nonsmoking Asian woman presented with a cough, and after diagnosis and surgical treatment, completed four cycles of adjuvant cisplatin and etoposide chemotherapy. She subsequently developed recurrence with bony metastases of exclusively <i>ALK</i>-positive LCNEC. Alectinib was started, and the patient experienced a partial response. |
| first_indexed | 2024-03-09T22:14:13Z |
| format | Article |
| id | doaj.art-529d17fe3b684219a7a9f5eb4e3e079f |
| institution | Directory Open Access Journal |
| issn | 1198-0052 1718-7729 |
| language | English |
| last_indexed | 2024-03-09T22:14:13Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Oncology |
| spelling | doaj.art-529d17fe3b684219a7a9f5eb4e3e079f2023-11-23T19:27:00ZengMDPI AGCurrent Oncology1198-00521718-77292022-02-0129284885210.3390/curroncol29020072A Case of ALK-Rearranged Combined Lung Adenocarcinoma and Neuroendocrine Carcinoma with Diffuse Bone Metastasis and Partial Response to AlectinibChloe A. Lim0Norbert Banyi1Tracy Tucker2Diana N. Ionescu3Barbara Melosky4MD Undergraduate Program, Faculty of Medicine, University of British Columbia, Vancouver, BC V6T 1Z1, CanadaMD Undergraduate Program, Faculty of Medicine, University of British Columbia, Vancouver, BC V6T 1Z1, CanadaCancer Genetics and Genomics Laboratory, Department of Pathology and Laboratory Medicine, BC Cancer, Vancouver, BC V6T 1Z1, CanadaDepartment of Pathology, BC Cancer, Vancouver, BC V6T 1Z1, CanadaMedical Oncology, BC Cancer, Vancouver, BC V6T 1Z1, CanadaWe report a rare case of stage IV pulmonary combined large-cell neuroendocrine carcinoma (LCNEC) and adenocarcinoma (ACA), both demonstrating anaplastic lymphoma kinase (<i>ALK</i>) rearrangement by IHC and FISH. This 61-year-old lifelong nonsmoking Asian woman presented with a cough, and after diagnosis and surgical treatment, completed four cycles of adjuvant cisplatin and etoposide chemotherapy. She subsequently developed recurrence with bony metastases of exclusively <i>ALK</i>-positive LCNEC. Alectinib was started, and the patient experienced a partial response.https://www.mdpi.com/1718-7729/29/2/72neuroendocrineadenocarcinomadriver mutationALKLCNEC |
| spellingShingle | Chloe A. Lim Norbert Banyi Tracy Tucker Diana N. Ionescu Barbara Melosky A Case of ALK-Rearranged Combined Lung Adenocarcinoma and Neuroendocrine Carcinoma with Diffuse Bone Metastasis and Partial Response to Alectinib Current Oncology neuroendocrine adenocarcinoma driver mutation ALK LCNEC |
| title | A Case of ALK-Rearranged Combined Lung Adenocarcinoma and Neuroendocrine Carcinoma with Diffuse Bone Metastasis and Partial Response to Alectinib |
| title_full | A Case of ALK-Rearranged Combined Lung Adenocarcinoma and Neuroendocrine Carcinoma with Diffuse Bone Metastasis and Partial Response to Alectinib |
| title_fullStr | A Case of ALK-Rearranged Combined Lung Adenocarcinoma and Neuroendocrine Carcinoma with Diffuse Bone Metastasis and Partial Response to Alectinib |
| title_full_unstemmed | A Case of ALK-Rearranged Combined Lung Adenocarcinoma and Neuroendocrine Carcinoma with Diffuse Bone Metastasis and Partial Response to Alectinib |
| title_short | A Case of ALK-Rearranged Combined Lung Adenocarcinoma and Neuroendocrine Carcinoma with Diffuse Bone Metastasis and Partial Response to Alectinib |
| title_sort | case of alk rearranged combined lung adenocarcinoma and neuroendocrine carcinoma with diffuse bone metastasis and partial response to alectinib |
| topic | neuroendocrine adenocarcinoma driver mutation ALK LCNEC |
| url | https://www.mdpi.com/1718-7729/29/2/72 |
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