Transcriptome and Lipid Metabolomics-Based Discovery: Glycyrrhizic Acid Alleviates Tripterygium Glycoside Tablet-Induced Acute Liver Injury by Regulating the Activities of CYP and the Metabolism of Phosphoglycerides

Transcriptome and Lipid Metabolomics-Based Discovery: Glycyrrhizic Acid Alleviates Tripterygium Glycoside Tablet-Induced Acute Liver Injury by Regulating the Activities of CYP and the Metabolism of Phosphoglycerides

Background: Glycyrrhizic acid (GA) has been reported to be liver protective; however, the characters and underlying mechanisms of GA against tripterygium glycoside tablet (TGT)-induced acute liver injury remain unelucidated.Hypothesis/Purpose: We assumed that GA could relieve TGT-induced acute liver...

Full description

Bibliographic Details
Main Authors: Qiaoli Shi, Qixin Wang, Jiayun Chen, Fei Xia, Chong Qiu, Min Li, Minghong Zhao, Qian Zhang, Piao Luo, Tianming Lu, Ying Zhang, Liting Xu, Xueling He, Tianyu Zhong, Na Lin, Qiuyan Guo
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-02-01
Series:Frontiers in Pharmacology
Subjects:
liver injury
glycyrrhizic acid
tripterygium glycoside tablet
lipid metabolomics
transcriptome
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.822154/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.822154/full

Similar Items