Aberrant α-Adrenergic Hypertrophic Response in Cardiomyocytes from Human Induced Pluripotent Cells

Aberrant α-Adrenergic Hypertrophic Response in Cardiomyocytes from Human Induced Pluripotent Cells

Cardiomyocytes from human embryonic stem cells (hESC-CMs) and induced pluripotent stem cells (hiPSC-CMs) represent new models for drug discovery. Although hypertrophy is a high-priority target, we found that hiPSC-CMs were systematically unresponsive to hypertrophic signals such as the α-adrenocepto...

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Bibliographic Details
Main Authors: Gabor Földes, Elena Matsa, János Kriston-Vizi, Thomas Leja, Stefan Amisten, Ljudmila Kolker, Thusharika Kodagoda, Nazanin F. Dolatshad, Maxime Mioulane, Karine Vauchez, Tamás Arányi, Robin Ketteler, Michael D. Schneider, Chris Denning, Sian E. Harding
Format: Article
Language:English
Published: Elsevier 2014-11-01
Series:Stem Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671114002872

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http://www.sciencedirect.com/science/article/pii/S2213671114002872

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