Myrislignan targets extracellular signal-regulated kinase (ERK) and modulates mitochondrial function to dampen osteoclastogenesis and ovariectomy-induced osteoporosis

Myrislignan targets extracellular signal-regulated kinase (ERK) and modulates mitochondrial function to dampen osteoclastogenesis and ovariectomy-induced osteoporosis

Abstract Background Activated osteoclasts cause excessive bone resorption, and disrupt bone homeostasis, leading to osteoporosis. The extracellular signal-regulated kinase (ERK) signaling is the classical pathway related to osteoclast differentiation, and mitochondrial reactive oxygen species are cl...

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Bibliographic Details
Main Authors: Tao Yang, Weiwei Chen, Kai Gan, Chaofeng Wang, Xiaoxiao Xie, Yuangang Su, Haoyu Lian, Jiake Xu, Jinmin Zhao, Qian Liu
Format: Article
Language:English
Published: BMC 2023-11-01
Series:Journal of Translational Medicine
Subjects:
ERK
Mitochondria
Myrislignan
LM22B-10
Osteoclast
Osteoporosis
Online Access:https://doi.org/10.1186/s12967-023-04706-2

Internet

https://doi.org/10.1186/s12967-023-04706-2

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