TLR7 modulates extramedullary splenic erythropoiesis in P. yoelii NSM-infected mice through the regulation of iron metabolism of macrophages with IFN-γ

TLR7 modulates extramedullary splenic erythropoiesis in P. yoelii NSM-infected mice through the regulation of iron metabolism of macrophages with IFN-γ

Splenomegaly is a prominent clinical manifestation of malaria and the causes remain incompletely clear. Anemia is induced in malaria and extramedullary splenic erythropoiesis is compensation for the loss of erythrocytes. However, the regulation of extramedullary splenic erythropoiesis in malaria is...

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Bibliographic Details
Main Authors: Jiajie Li, Lin Liu, Junmin Xing, Dianhui Chen, Chao Fang, Feng Mo, Yumei Gong, Zhengrong Tan, Guikuan Liang, Wei Xiao, Shanni Tang, Haixia Wei, Shan Zhao, Hongyan Xie, Xingfei Pan, Xiaomao Yin, Jun Huang
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-04-01
Series:Frontiers in Immunology
Subjects:
malaria
TLR7
extramedullary splenic erythropoiesis
IFN-γ
macrophages
iron metabolism
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1123074/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2023.1123074/full

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