First Total Synthesis and Biological Screening of a Proline-Rich Cyclopeptide from a Caribbean Marine Sponge

First Total Synthesis and Biological Screening of a Proline-Rich Cyclopeptide from a Caribbean Marine Sponge

A natural heptacyclopeptide, stylissamide G (7), previously isolated from the Bahamian marine sponge Stylissa caribica from the Caribbean Sea, was synthesized via coupling of the tetrapeptide l-phenylalanyl-l-prolyl-l-phenylalanyl-l-proline methyl ester with the tripeptide Boc-l-leucyl-l-isoleucyl-l...

Full description

Bibliographic Details
Main Authors: Rajiv Dahiya, Sunil Singh, Ajay Sharma, Suresh V. Chennupati, Sandeep Maharaj
Format: Article
Language:English
Published: MDPI AG 2016-12-01
Series:Marine Drugs
Subjects:
stylissamide G
cycloheptapeptide
Stylissa caribica
peptide synthesis
macrocyclization
pharmacological activity
marine sponge
Online Access:http://www.mdpi.com/1660-3397/14/12/228

Internet

http://www.mdpi.com/1660-3397/14/12/228

Similar Items