Integrative analysis of DNA replication origins and ORC-/MCM-binding sites in human cells reveals a lack of overlap

Integrative analysis of DNA replication origins and ORC-/MCM-binding sites in human cells reveals a lack of overlap

Based on experimentally determined average inter-origin distances of ~100 kb, DNA replication initiates from ~50,000 origins on human chromosomes in each cell cycle. The origins are believed to be specified by binding of factors like the origin recognition complex (ORC) or CTCF or other features lik...

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Bibliographic Details
Main Authors: Mengxue Tian, Zhenjia Wang, Zhangli Su, Etsuko Shibata, Yoshiyuki Shibata, Anindya Dutta, Chongzhi Zang
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2024-04-01
Series:eLife
Subjects:
origins of replication
DNA replication
ORC
MCM2-7
integrative analysis
Online Access:https://elifesciences.org/articles/89548

Internet

https://elifesciences.org/articles/89548

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