Oxidosqualene Cyclase (OSC) Inhibitors for the Treatment of Dyslipidemia

Oxidosqualene Cyclase (OSC) Inhibitors for the Treatment of Dyslipidemia

Novel inhibitors of oxidosqualene cyclase (OSC) for the treatment of dyslipidemia are reported. Starting point for the chemistry program was a set of compounds derived from a fungicide project which, in addition to high affinity for OSC from Candida albicans, also showed high affinity for...

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Bibliographic Details
Main Authors: Henrietta Dehmlow, Ralf Thoma, Armin Ruf, Narendra Panday, Elisabeth Von Der Mark, Olivier Morand, Hans Peter Märki, Manfred Kansy, Peter Hartman, Philippe Coassolo, Alexander Chucholowski, Denise Blum-Kaelin, Johannes Aebi, Jean Ackermann, Tanja Schulz-Gasch
Format: Article
Language:deu
Published: Swiss Chemical Society 2005-03-01
Series:CHIMIA
Subjects:
Dyslipidemia
Medicinal chemistry
Oxidosqualene cyclase
Structure-activity relationship
Online Access:https://chimia.ch/chimia/article/view/3949

Internet

https://chimia.ch/chimia/article/view/3949

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