c-Abl Regulates the Pathological Deposition of TDP-43 via Tyrosine 43 Phosphorylation

c-Abl Regulates the Pathological Deposition of TDP-43 via Tyrosine 43 Phosphorylation

Non-receptor tyrosine kinase, c-Abl plays a role in the pathogenesis of several neurodegenerative disorders such as Alzheimer’s disease and Parkinson’s disease. Here, we found that TDP-43, which was one of the main proteins comprising pathological deposits in amyotrophic lateral sclerosis (ALS), is...

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Bibliographic Details
Main Authors: Saebom Lee, Hye Guk Ryu, Sin Ho Kweon, Hyerynn Kim, Hyeonwoo Park, Kyung-Ha Lee, Sang-Min Jang, Chan Hyun Na, Sangjune Kim, Han Seok Ko
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Cells
Subjects:
c-Abl
TDP-43
phosphorylation
mislocalization
amyotrophic lateral sclerosis
Online Access:https://www.mdpi.com/2073-4409/11/24/3972

Internet

https://www.mdpi.com/2073-4409/11/24/3972

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