Evaluation of microsatellite instability in routine examinations of surgical samples

Evaluation of microsatellite instability in routine examinations of surgical samples

Context: Approximately 20%–30% of colon cancer cases have a hereditary basis. The genetic defect may involve mismatch repair (MMR) genes, which results in microsatellite instability (MSI). MMR-deficient colorectal cancer may occur due to germline mutation (Lynch syndrome) or be a sporadic one. A tum...

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Bibliographic Details
Main Authors: Pawel Wlaszczuk, Aleksandra Kuzbinska, Zuzanna Dobrosz, Piotr Palen, Krzysztof Pawlicki
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2022-01-01
Series:Indian Journal of Pathology and Microbiology
Subjects:
colorectal carcinoma (crc)
lynch syndrome (ls)
microsatellite instability (msi)
mismatch repair (mmr)
Online Access:http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2022;volume=65;issue=1;spage=87;epage=92;aulast=Wlaszczuk

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http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2022;volume=65;issue=1;spage=87;epage=92;aulast=Wlaszczuk

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