Binding-driven reactivity attenuation enables NMR identification of selective drug candidates for nucleic acid targets

Binding-driven reactivity attenuation enables NMR identification of selective drug candidates for nucleic acid targets

NMR spectroscopy could be a robust and reliable method for binding detection in drug discovery, but DNA/RNA targets remain challenging to analyze. Here, the authors explore the perturbation of the ligand reactivity caused by complex formation as a binding indicator to identify best binders within mi...

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Bibliographic Details
Main Authors: Laura Díaz-Casado, Andrés G. Santana, Irene Gómez-Pinto, Alejandro Villacampa, Francisco Corzana, Jesús Jiménez-Barbero, Carlos González, Juan Luis Asensio
Format: Article
Language:English
Published: Nature Portfolio 2022-10-01
Series:Communications Chemistry
Online Access:https://doi.org/10.1038/s42004-022-00755-8

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https://doi.org/10.1038/s42004-022-00755-8

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