Principal Component Analysis (PCA) of Molecular Descriptors for Improving Permeation through the Blood–Brain Barrier of Quercetin Analogues

Principal Component Analysis (PCA) of Molecular Descriptors for Improving Permeation through the Blood–Brain Barrier of Quercetin Analogues

Despite its beneficial pharmacological effects in the brain, partly by modulating inositol phosphate multikinase (IPMK) activity, the therapeutic use of quercetin is limited due to its poor solubility, low oral bioavailability, and low permeability through the blood–brain barrier (BBB). We aimed to...

Full description

Bibliographic Details
Main Authors: Nebojša Pavlović, Nastasija Milošević Sopta, Darko Mitrović, Dragana Zaklan, Ana Tomas Petrović, Nebojša Stilinović, Saša Vukmirović
Format: Article
Language:English
Published: MDPI AG 2023-12-01
Series:International Journal of Molecular Sciences
Subjects:
quercetin
neuroprotection
IPMK
molecular docking
blood–brain barrier
PCA
Online Access:https://www.mdpi.com/1422-0067/25/1/192

Internet

https://www.mdpi.com/1422-0067/25/1/192

Similar Items