Isolation of a novel human prion strain from a PRNP codon 129 heterozygous vCJD patient.

Isolation of a novel human prion strain from a PRNP codon 129 heterozygous vCJD patient.

The epizootic prion disease of cattle, bovine spongiform encephalopathy (BSE), caused variant Creutzfeldt-Jakob disease (vCJD) in humans following dietary exposure. Codon 129 polymorphism of the human prion protein gene (PRNP), encoding either methionine (M) or valine (V), dictates the propagation o...

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Bibliographic Details
Main Authors: Fuquan Zhang, Susan Joiner, Jacqueline M Linehan, Florin Pintilii, Tamsin Nazari, Fabio Argentina, Connor Preston, Maged Taema, Thomas J Cunningham, Emmanuel A Asante, Tzehow Mok, Simon Mead, Sebastian Brandner, John Collinge, Jonathan D F Wadsworth
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-02-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1012904

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https://doi.org/10.1371/journal.ppat.1012904

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