Ligand and structure-based approaches for the exploration of structure–activity relationships of fusidic acid derivatives as antibacterial agents

Ligand and structure-based approaches for the exploration of structure–activity relationships of fusidic acid derivatives as antibacterial agents

Introduction: Fusidic acid (FA) has been widely applied in the clinical prevention and treatment of bacterial infections. Nonetheless, its clinical application has been limited due to its narrow antimicrobial spectrum and some side effects.Purpose: Therefore, it is necessary to explore the structure...

Full description

Bibliographic Details
Main Authors: Wende Zheng, Borong Tu, Zhen Zhang, Jinxuan Li, Zhenping Yan, Kaize Su, Duanyu Deng, Ying Sun, Xu Wang, Bingjie Zhang, Kun Zhang, Wing-Leung Wong, Panpan Wu, Weiqian David Hong, Song Ang
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Chemistry
Subjects:
fusidic acid
derivatives
pharmacophore model
antibacterial
structure–activity relationships
Online Access:https://www.frontiersin.org/articles/10.3389/fchem.2022.1094841/full

Internet

https://www.frontiersin.org/articles/10.3389/fchem.2022.1094841/full

Similar Items