Clinical pharmacology of vc-MMAE antibody–drug conjugates in cancer patients: learning from eight first-in-human Phase 1 studies

Clinical pharmacology of vc-MMAE antibody–drug conjugates in cancer patients: learning from eight first-in-human Phase 1 studies

vc-MMAE antibody–drug conjugates (ADCs) consist of a monoclonal antibody (mAb) covalently bound with a potent anti-mitotic toxin (MMAE) through a protease-labile valine-citrulline (vc) linker. The objective of this study was to characterize the pharmacokinetics (PK) and explore exposure–response rel...

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Bibliographic Details
Main Authors: Chunze Li, Cindy Zhang, Zao Li, Divya Samineni, Dan Lu, Bei Wang, Shang-Chiung Chen, Rong Zhang, Priya Agarwal, Bernard M. Fine, Sandhya Girish
Format: Article
Language:English
Published: Taylor & Francis Group 2020-01-01
Series:mAbs
Subjects:
Antibody–drug conjugate
vc-MMAE ADCs
pharmacokinetics
exposure–response analysis
first-in-human studies
Online Access:https://www.tandfonline.com/doi/10.1080/19420862.2019.1699768

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https://www.tandfonline.com/doi/10.1080/19420862.2019.1699768

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