Mogrol Attenuates Osteoclast Formation and Bone Resorption by Inhibiting the TRAF6/MAPK/NF-κB Signaling Pathway In vitro and Protects Against Osteoporosis in Postmenopausal Mice

Mogrol Attenuates Osteoclast Formation and Bone Resorption by Inhibiting the TRAF6/MAPK/NF-κB Signaling Pathway In vitro and Protects Against Osteoporosis in Postmenopausal Mice

Osteoporosis is a serious public health problem that results in fragility fractures, especially in postmenopausal women. Because the current therapeutic strategy for osteoporosis has various side effects, a safer and more effective treatment is worth exploring. It is important to examine natural pla...

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Bibliographic Details
Main Authors: Yongjie Chen, Linlin Zhang, Zongguang Li, Zuoxing Wu, Xixi Lin, Na Li, Rong Shen, Guojun Wei, Naichun Yu, Fengqing Gong, Gang Rui, Ren Xu, Guangrong Ji
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Pharmacology
Subjects:
osteoporosis
osteoclast
mogrol
TRAF6
RANKL
MAPK
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.803880/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.803880/full

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