Vero cell-adapted SARS-CoV-2 strain shows increased viral growth through furin-mediated efficient spike cleavage

Vero cell-adapted SARS-CoV-2 strain shows increased viral growth through furin-mediated efficient spike cleavage

ABSTRACTSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) utilizes several host proteases to cleave the spike (S) protein to enter host cells. SARS-CoV-2 S protein is cleaved into S1 and S2 subunits by furin, which is closely involved in the pathogenicity of SARS-CoV-2. However, the effec...

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Bibliographic Details
Main Authors: Shohei Minami, Tomohiro Kotaki, Yusuke Sakai, Shinya Okamura, Shiho Torii, Chikako Ono, Daisuke Motooka, Rina Hamajima, Ryotaro Nouda, Jeffery A. Nurdin, Moeko Yamasaki, Yuta Kanai, Hirotaka Ebina, Yusuke Maeda, Toru Okamoto, Taro Tachibana, Yoshiharu Matsuura, Takeshi Kobayashi
Format: Article
Language:English
Published: American Society for Microbiology 2024-04-01
Series:Microbiology Spectrum
Subjects:
severe acute respiratory syndrome virus-2 (SARS-CoV-2)
spike (S) protein
viral replication
infection
pathogenicity
Online Access:https://journals.asm.org/doi/10.1128/spectrum.02859-23

Internet

https://journals.asm.org/doi/10.1128/spectrum.02859-23

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