Small molecule drug discovery targeting the JAK-STAT pathway

Small molecule drug discovery targeting the JAK-STAT pathway

The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway functions as a central hub for transmitting signals from more than 50 cytokines, playing a pivotal role in maintaining hematopoiesis, immune balance, and tissue homeostasis. Dysregulation of this pathway has been im...

Full description

Bibliographic Details
Main Authors: You Lv, Pengbing Mi, Jeffrey J. Babon, Guohuang Fan, Jianxun Qi, Longxing Cao, Jiajia Lang, Jin Zhang, Faming Wang, Bostjan Kobe
Format: Article
Language:English
Published: Elsevier 2024-06-01
Series:Pharmacological Research
Subjects:
JAK-STAT pathway
JAK inhibitors
Kinase
Autoimmune diseases
Drug discovery
Online Access:http://www.sciencedirect.com/science/article/pii/S1043661824001610

Internet

http://www.sciencedirect.com/science/article/pii/S1043661824001610

Similar Items