Widespread discrepancy in Nnt genotypes and genetic backgrounds complicates granzyme A and other knockout mouse studies

Widespread discrepancy in Nnt genotypes and genetic backgrounds complicates granzyme A and other knockout mouse studies

Granzyme A (GZMA) is a serine protease secreted by cytotoxic lymphocytes, with Gzma-/- mouse studies having informed our understanding of GZMA’s physiological function. We show herein that Gzma-/- mice have a mixed C57BL/6J and C57BL/6N genetic background and retain the full-length nicotinamide nucl...

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Bibliographic Details
Main Authors: Daniel J Rawle, Thuy T Le, Troy Dumenil, Cameron Bishop, Kexin Yan, Eri Nakayama, Phillip I Bird, Andreas Suhrbier
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-02-01
Series:eLife
Subjects:
granzyme A
nicotinamide nucleotide transhydrogenase
chikungunya
inflammation
C57BL/6J
C57BL/6N
Online Access:https://elifesciences.org/articles/70207

Internet

https://elifesciences.org/articles/70207

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