Small-Molecule-Directed Endogenous Regeneration of Visual Function in a Mammalian Retinal Degeneration Model

Small-Molecule-Directed Endogenous Regeneration of Visual Function in a Mammalian Retinal Degeneration Model

Degenerative retinal diseases associated with photoreceptor loss are a leading cause of visual impairment worldwide, with limited treatment options. Phenotypic profiling coupled with medicinal chemistry were used to develop a small molecule with proliferative effects on retinal stem/progenitor cells...

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Bibliographic Details
Main Authors: Daphna Mokady, Jason Charish, Patrick Barretto-Burns, Kenneth N. Grisé, Brenda L. K. Coles, Susanne Raab, Arturo Ortin-Martinez, Alex Müller, Bernhard Fasching, Payal Jain, Micha Drukker, Derek van der Kooy, Matthias Steger
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:International Journal of Molecular Sciences
Subjects:
small molecule
regenerative medicine
inherited retinal diseases
retina
photoreceptors
functional recovery
Online Access:https://www.mdpi.com/1422-0067/25/3/1521

Internet

https://www.mdpi.com/1422-0067/25/3/1521

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