Examining the Relationship between Circulating CD4− CD8− Double-Negative T Cells and Outcomes of Immuno-Checkpoint Inhibitor Therapy—Looking for Biomarkers and Therapeutic Targets in Metastatic Melanoma

Examining the Relationship between Circulating CD4− CD8− Double-Negative T Cells and Outcomes of Immuno-Checkpoint Inhibitor Therapy—Looking for Biomarkers and Therapeutic Targets in Metastatic Melanoma

Background: The role of circulating CD4<b>−</b>/CD8<b>−</b> double-negative T cells (DNTs) in the immune response to melanoma is poorly understood, as are the effects of checkpoint inhibitors on T cell subpopulations. Methods: We performed a basal and longitudinal assessment...

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Bibliographic Details
Main Authors: Sabino Strippoli, Annarita Fanizzi, Antonio Negri, Davide Quaresmini, Annalisa Nardone, Andrea Armenio, Angela Monica Sciacovelli, Raffaella Massafra, Ivana De Risi, Giacoma De Tullio, Anna Albano, Michele Guida
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Cells
Subjects:
double negative T cells
checkpoint inhibitors
melanoma
immunotherapy resistance
Online Access:https://www.mdpi.com/2073-4409/10/2/406

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https://www.mdpi.com/2073-4409/10/2/406

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