Orthotopic transplantation of the bioengineered lung using a mouse-scale perfusion-based bioreactor and human primary endothelial cells

Orthotopic transplantation of the bioengineered lung using a mouse-scale perfusion-based bioreactor and human primary endothelial cells

Abstract Whole lung engineering and the transplantation of its products is an ambitious goal and ultimately a viable solution for alleviating the donor-shortage crisis for lung transplants. There are several limitations currently impeding progress in the field with a major obstacle being efficient r...

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Bibliographic Details
Main Authors: Fumiko Tomiyama, Takaya Suzuki, Tatsuaki Watanabe, Jun Miyanaga, Anna Suzuki, Takayasu Ito, Sho Murai, Yuyo Suzuki, Hiromichi Niikawa, Hisashi Oishi, Hirotsugu Notsuda, Yui Watanabe, Takashi Hirama, Ken Onodera, Takeo Togo, Masafumi Noda, Thomas K. Waddell, Golnaz Karoubi, Yoshinori Okada
Format: Article
Language:English
Published: Nature Portfolio 2024-04-01
Series:Scientific Reports
Subjects:
Lung bioengineering
Vascular engineering
Decellularization
Perfusion-based Bioreactor
Transplantation
Box-counting analysis
Online Access:https://doi.org/10.1038/s41598-024-57084-0

Internet

https://doi.org/10.1038/s41598-024-57084-0

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