Mitochondria-targeted photodynamic therapy triggers GSDME-mediated pyroptosis and sensitizes anti-PD-1 therapy in colorectal cancer

Mitochondria-targeted photodynamic therapy triggers GSDME-mediated pyroptosis and sensitizes anti-PD-1 therapy in colorectal cancer

Background The effectiveness of immune checkpoint inhibitors in colorectal cancer (CRC) is limited due to the low tumor neoantigen load and low immune infiltration in most microsatellite-stable (MSS) tumors. This study aimed to develop a mitochondria-targeted photodynamic therapy (PDT) approach to p...

Full description

Bibliographic Details
Main Authors: Xin Wang, Dawei Zhang, Xiaodi Zhao, Yuanyuan Lu, Yun Zhou, Hua Han, Pei Wang, Wenyao Zhang, Boda Wang, Danxiu Li, Tianyu Cao, Mingfeng Bai
Format: Article
Language:English
Published: BMJ Publishing Group 2024-03-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/12/3/e008054.full

Internet

https://jitc.bmj.com/content/12/3/e008054.full

Similar Items