Autophagy enhanced by curcumin ameliorates inflammation in atherogenesis via the TFEB–P300–BRD4 axis

Autophagy enhanced by curcumin ameliorates inflammation in atherogenesis via the TFEB–P300–BRD4 axis

Disturbance of macrophage-associated lipid metabolism plays a key role in atherosclerosis. Crosstalk between autophagy deficiency and inflammation response in foam cells (FCs) through epigenetic regulation is still poorly understood. Here, we demonstrate that in macrophages, oxidized low-density lip...

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Bibliographic Details
Main Authors: Xuesong Li, Ruigong Zhu, Hong Jiang, Quanwen Yin, Jiaming Gu, Jiajing Chen, Xian Ji, Xuan Wu, Haiping Fu, Hui Wang, Xin Tang, Yuanqing Gao, Bingjian Wang, Yong Ji, Hongshan Chen
Format: Article
Language:English
Published: Elsevier 2022-05-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Macrophage
Autophagy
TFEB
P300
BRD4
Inflammation
Online Access:http://www.sciencedirect.com/science/article/pii/S221138352100486X

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http://www.sciencedirect.com/science/article/pii/S221138352100486X

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