ORFeus: a computational method to detect programmed ribosomal frameshifts and other non-canonical translation events

Abstract Background In canonical protein translation, ribosomes initiate translation at a specific start codon, maintain a single reading frame throughout elongation, and terminate at the first in-frame stop codon. However, ribosomal behavior can deviate at each of these steps, sometimes in a progra...

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Bibliographic Details
Main Authors: Mary O. Richardson, Sean R. Eddy
Format: Article
Language:English
Published: BMC 2023-12-01
Series:BMC Bioinformatics
Subjects:
Online Access:https://doi.org/10.1186/s12859-023-05602-8